DYNASORE and CALL DIVISION: Implications for Cancer Research
DYNASORES Dynasore is a small molecule that is commonly used as a dynamin inhibitor in cell biology research. Dynamin is a GTPase enzyme that plays a critical role in clathrin-mediated endocytosis, a process by which cells internalize extracellular material. Dynasore works by binding to the GTPase domain of dynamin, inhibiting its GTPase activity and preventing the formation of the dynamin ring structure necessary for membrane fission and vesicle formation. Dynasore was first identified in a high-throughput screening of small molecule libraries for compounds that could inhibit dynamin-dependent endocytosis. Since then, it has been widely used as a tool to study the role of dynamin in a variety of cellular processes, including receptor-mediated endocytosis, synaptic vesicle recycling, and cell division. Dynasore has also shown potential as a therapeutic agent, particularly in the treatment of viral infections. In several studies, dynasore has been shown to inhibit the entry of various...
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